The New Orleans Saints will face the Buffalo Bills in Week 12 of the 2021 NFL season on Thursday, November 25th, 2021. BettorCenter's Louie Diamond breaks it down!

Saints are 5-5.

Bills are 6-4.

Time: 8:20 p.m. ET.

Stadium: Caesars Superdome, New Orleans, Louisiana.

TV: NBC.

Spread: Bills -6.

Total: 45.

Odds courtesy of FanDuel Sportsbook

Pick: Buffalo Bills -6