When: Monday, November 15, 2021 at 8:15PM ET

Where: Levi’s Stadium, San Francisco, California

How: ESPN.

Spread: Rams -3.5

Total: 50.5

Odds courtesy of FanDuel Sportsbook

Rams Spotlight

The Los Angeles Rams were just stunned on their own turf to the Tennessee Titans as 7-point favorites. The Rams offense has been solid on the road where they rank 9th in points per game, 4th in passing yards, 10th in rushing yards, and 3rd in yards per play. Defensively on the road, the Rams rank 3rd in points allowed, 19th in passing yards allowed, 1st in rushing yards allowed, and 8th in yards per play.

49ers Spotlight

The San Francisco 49ers are coming off of a dreadful loss at home against the Kyler Murray-less Arizona Cardinals, even though they were 5.5-point favorites. At home, the 49er’s offense hasn’t been anything to brag home about where their offense ranks 22nd in points per game, 12th in passing yards, 27th in rushing yards, and 14th in yards per play. Their defense at home has been worse, ranking 26th in points allowed, 5th in passing yards allowed, 27th in rushing yards allowed, and 12th in yards per play. 

Final Say

San Francisco has been owning this series lately, winning seven of their last 10 meetings, winning by an average of 3-points per game. The 49ers are actually 8-3 ATS in their last 11 games versus the Rams. The Rams seem to be playing down to their opponents level of competition, going just 1-6 ATS in their last seven games versus a team with a losing record. Then you have the underdog has covered in their last four meetings between these two teams. The trends are pointing to the 49ers, but Los Angeles is the better team, with the better defense here. The Rams are coming off embarrassing home loss, but they only gave up 192 yards in that game. Meanwhile, they own a +5 turnover differential in their last five games compared the 49er’s -6 turnover differential. In the 49er’s last four games at home, they are 0-4 ATS. Rolling with the better team here.

Pick: Los Angeles Rams -3.5