When: Sunday, November 21, 2021 at 1:00PM ET.

Where: TIAA Bank Field, Jacksonville, Florida.

How: FOX.

Spread: 49ers -6.5.

Total: 45.5.

Odds courtesy of FanDuel Sportsbook

49ers Spotlight

The San Francisco 49ers are coming off a big divisional win over the Los Angeles Rams as 3.5-point underdogs, and now they’ll head to the east coast to take on the lowly Jaguars. On the road, the 49ers rank 21st in points per game, 13th in passing yards, 5th in rushing yards, and 2nd in yards per play. Defensively on the road, the 49ers rank 4th in points allowed, 7th in passing yards allowed, 27th in rushing yards allowed, and 11th in yards per play.

Jaguars Spotlight

The Jacksonville Jaguars couldn’t get it done against the Indianapolis Colts last night, but they did manage to cover the 10-point spread in the process. At home, the Jaguars rank 30th in points per game, 28th in pass yards, 10th in rush yards, and 20th in yards per play. On the defensive side at home, the Jaguars rank 17th in points allowed, 25th in pass yards allowed, 9th in rush yards allowed, and 22nd in yards per play.

Final Say

Jacksonville is a putrid 0-13 in their last 13 tries against an NFC opponent, and are 2-10 SU in their last 12 games at home. However, they have found themselves playing good football lately, going 4-2 ATS in their last six games. San Francisco has been solid on the road where they’ve gone 4-1 SU in their last five trips, while they have also be profitable against the Jaguars, going 4-1 ATS in their last five against them. The 49ers are coming off a prime-time victory against a divisional opponent, which has left them with one day less to prepare for this game. It is also an east-coast travel for them for the early slate of games. Defense has been the Jaguars identity lately, giving up just 275 yards per game in their last four games, which is 4th best in the league, the 49ers rank 19th during that span. Bad spot for the 49ers, so I’ll gladly take the free points here.

Pick: Jacksonville Jaguars +6.5