When: Thursday, December 23rd, 2021 at 8:20PM ET.

Where: Nissan Stadium, Nashville, TN.

How: FOX, NFL Network.

Spread: 49ers -3.

Total: 44.

Odds courtesy of FanDuel Sportsbook

49ers Spotlight

The San Francisco 49ers ended up getting serious with the Atlanta Falcons last week, propelling them to an ATS cover as 9-point favorites. On the road, the 49er’s offense ranks 12th in points per game, 11th in pass yards, 8th in rush yards, and 4th in yards per play. Defensively on the road, the 49ers rank 8th in points allowed, 8th in pass yards allowed, 21st in rush yards allowed, and 7th in yards per play.

Titans Spotlight

The Tennessee Titans couldn’t hold on to a lead against the Pittsburgh Steelers, losing on the road as 1-point underdogs. At home, the Titan’s offense ranks 21st in points per game, 19th in pass yards, 16th in rush yards, and 22nd in yards per play. Defensively at home, the Titans rank 4th in points allowed, 16th in pass yards allowed, 1st in rush yards allowed, and 4th in yards per play.

Final Say

The Titans are 7-3 SU in their last 10 games, but they are just 1-4 ATS in their last five games, and you can tell they are really struggling without Henry. They also own a -9 turnover differential in their last four games, while the 49ers haven’t lost the turnover battle in their last six games. The 49ers have been awesome on the road going 6-2 SU in their last eight games there, while they have owned the Titans historically, winning eight of their last 11 meetings while going 4-1 SU in their last five trips to Tennessee. It is hard to back a team that is turning over the ball like that, while the 49ers are doing just enough to not shoot themselves in the foot. The 49ers are making the late-season surge, while the Titans are limping to the finish line. Expect this vamped up 49ers team to roll through the Titans on the road.

Pick: San Francisco 49ers -3