New York Yankees vs. Cleveland Guardians Prediction and Picks - April 22, 2025
The New York Yankees and Cleveland Guardians continue their three-game series at Progressive Field on Tuesday, April 22, 2025. After dropping the opener 6–4, the Yankees aim to bounce back against a surging Guardians team that has won four straight and 10 of their last 13 games.
Game Details
Date: Tuesday, April 22, 2025
Time: 6:10 PM ET
Location: Progressive Field, Cleveland, OH
Broadcast: YES Network (Yankees), Bally Sports Great Lakes (Guardians), MLB.TV
Starting Pitchers
Yankees: Will Warren (RHP) – 1-0, 5.17 ERA, 1.40 WHIP over 15.2 innings
Guardians: Tanner Bibee (RHP) – 1-2, 5.85 ERA, 1.50 WHIP over 20.0 innings
Yankees Overview
The Yankees enter the game with a 14–9 record, leading the AL East. Despite missing key players like Giancarlo Stanton and Gerrit Cole due to injuries, the team has maintained strong performance. Aaron Judge continues to be a standout, reaching base in 19 consecutive games and leading the majors with a .384 batting average and 25 RBIs. The team boasts a .257 batting average and leads MLB with a .199 opposing batting average, averaging 1.73 home runs and allowing just 6.36 hits per game.
In the series opener, Clarke Schmidt struggled, allowing five runs over four innings, including home runs to José Ramírez and Kyle Manzardo. The Yankees' offense showed resilience with late homers from Jasson Domínguez and Jazz Chisholm Jr., but went 0-for-5 with runners in scoring position.
Will Warren takes the mound for his second start of the season. In his previous outing, he allowed three runs over 5.2 innings, relying heavily on his knuckle curve.
Guardians Overview
The Guardians hold a 13–9 record, sitting second in the AL Central. They have been formidable at home with a 6–1 record. Offensively, they rank 15th in batting average (.238) and 21st in runs per game (4.10), but have shown the ability to score in key moments. Defensively, they allow a .248 batting average and 4.29 runs per game, with a team ERA of 3.98.
In the series opener, José Ramírez and Kyle Manzardo each hit home runs, with Manzardo homering in three consecutive games. Steven Kwan continues to lead the offense with a .325 average and 158 wRC+.
Tanner Bibee will start for the Guardians. He has struggled early in the season, allowing 13 earned runs over his last three starts. Bibee will need to improve his command to contain the Yankees' potent lineup.
Betting Odds
Moneyline: Yankees -110, Guardians -110
Run Line: Yankees -1.5 (+146), Guardians +1.5 (-178)
Over/Under: 8 runs (Over -110, Under -110)
Prediction
This matchup features two teams with strong starts to the season. The Yankees' powerful offense, led by Aaron Judge, faces a challenge against a Guardians team that has been tough at home. With both starting pitchers having similar early-season struggles, the game could hinge on bullpen performance and timely hitting.
Final Score Prediction: Yankees 6, Guardians 4
Best Bets:
Moneyline: Yankees -110
Over/Under: Over 8 runs
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